Additivity Principles in Biochemistry

Additivity principles in biochemistry.

We cannot yet reliably fold proteins or RNA molecules by computer, predict ligand binding affinities, compute conformational transitions, or use the sequence information in the Human Genome very effectively to understand biomolecular function and disease. Why not? Perhaps some of our models in computational biology are based on flawed assumptions. Thermodynamic additivity principles are the fou...

Principles of Biochemistry

Additivity and non-additivity for perverse signatures

A well-known property of the signature of closed oriented 4n-dimensional manifolds is Novikov additivity, which states that if a manifold is split into two manifolds with boundary along an oriented smooth hypersurface, then the signature of the original manifold equals the sum of the signatures of the resulting manifolds with boundary. Wall showed that this property is not true of signatures on...

Additivity in Psychological Measurement

Shows how the Rasch model i s a u n i t m a i n t a i n i n g process (Thurstone, 1931) which enables the construct i o n of a d d i t i v i t y (Campbell, 1920) and hence fundamental measurement (Luce and Tukey, 1964). Provides the b a s i c s t a t i s t i c s f o r determining the extent to which a d d i t i v i t y has been approximated w i t h p a r t i c u l a r data. (A note reviews the ...

Multistability, cross-modal binding and the additivity of conjoined grouping principles.

We present a sceptical view of multimodal multistability--drawing most of our examples from the relation between audition and vision. We begin by summarizing some of the principal ways in which audio-visual binding takes place. We review the evidence that unambiguous stimulation in one modality may affect the perception of a multistable stimulus in another modality. Cross-modal influences of on...